MEDICAL PHYSIOLOGY

Detailed explanation-1: -Tropomyosin blocks myosin binding sites on actin molecules, preventing cross-bridge formation and preventing contraction in a muscle without nervous input. Troponin binds to tropomyosin and helps to position it on the actin molecule; it also binds calcium ions.

Detailed explanation-2: -1 Tropomyosin. TM regulates smooth muscle contraction by blocking the myosin binding sites on actin, preventing actin–myosin interaction.

Detailed explanation-3: -Tropomyosin is a protein that winds around the chains of the actin filament and covers the myosin-binding sites to prevent actin from binding to myosin. Tropomyosin binds to troponin, which anchors the tropomyosin in place, to form a troponin-tropomyosin complex.

Detailed explanation-4: -Actin Associated Proteins. Tropomyosin (TM), a long fibrous protein lies along the long pitch double-helical thin filament spanning seven actin monomers and through end-to-end contacts continuously covers the actin filament in all muscles.