MEDICAL PHYSIOLOGY

Detailed explanation-1: -The greater part of lymphocyte development in mammals occurs in the specialized environments of the central lymphoid organs-the bone marrow (and the liver in the fetus) for B cells and the thymus for T cells.

Detailed explanation-2: -Organs and Tissues The bone marrow is extremely important to the immune system because all the body’s blood cells (including T and B lymphocytes) originate in the bone marrow. B lymphocytes remain in the marrow to mature, while T lymphocytes travel to the thymus.

Detailed explanation-3: -They develop from hematopoietic stem cells, which are produced in our bone marrow.

Detailed explanation-4: -Bone marrow is major organ for the development and maturation of B cells. B cells are generated from HSCs and developed in bone marrow before they egress into peripheral blood to reach peripheral lymphoid organs. Specific cellular niches for B-cell development include CXCL12-expressing cells and IL-7-expressing cells.

Detailed explanation-5: -All lymphocytes develop in bone marrow from immature cells called stem cells. Lymphocytes that mature in the thymus gland (behind the breastbone) are called T cells. Those that mature in bone marrow or the lymphatic organs are called B cells.