MEDICAL PHYSIOLOGY

Detailed explanation-1: -Gamma-aminobutyric acid (GABA) is the most common inhibitory neurotransmitter in your central nervous system. GABA lessens the ability of a nerve cell to receive, create or send chemical messages to other nerve cells.

Detailed explanation-2: -GABA-B receptors are present as autoreceptors that inhibit GABA release or heteroreceptors that reduce the release of glutamate, norepinephrine, serotonin, or dopamine.

Detailed explanation-3: -Excess glutamate and/or inadequate GABA can lead to overexcitation in the CNS, leading to seizure occurrence [6, 7, 14].

Detailed explanation-4: -GABA agonists were found to intensify seizures in some rodent and human cases. Absence and other generalized seizures in humans often worsened when treated with GABA transaminase inhibitors such as gamma-vinyl-GABA.

Detailed explanation-5: -Reductions of GABA mediated inhibition and decreased activity of GAD has been reported in studies of human epileptic brain tissue. Impairment of GABA functions produces seizures, whereas enhancement results in an anticonvulsant effect [31, 32].