MEDICAL PHYSIOLOGY

PHYSIOLOGY

RENAL AND ACID BASE PHYSIOLOGY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Active reabsorption of all of the following molecules takes place in the thick ascending limb of the loop of Henle
A
Ca+, Na+, H+
B
K+, Ca+, Cl-
C
Cl-, Na+ K+
D
Mg2+, HCO3-, Cl-
Explanation: 

Detailed explanation-1: -Thick ascending limb Sodium (Na+), potassium (K+) and chloride (Cl−) ions are reabsorbed by active transport. The predominant mechanism of active transport in this segment is through the Na+/K+/Cl− co-transporter NKCC2 as well as the sodium/hydrogen exchanger NHE3.

Detailed explanation-2: -Reabsorption in the thick ascending limb: A further 25% of the sodium and potassium is reabsorbed through the walls of the thick ascending limb of the loop of Henle via: Three-ion cotransporter (sodium/potassium/chloride) and the sodium/potassium ATPase, which as before maintains the sodium concentration gradient.

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