PHYSIOLOGY
RENAL AND ACID BASE PHYSIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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GFR ____ with relaxation of mesangial cells
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Increases
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Decreases
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Either A or B
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None of the above
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Explanation:
Detailed explanation-1: -Mesangial cells can generate interleukin 1 and platelet-derived growth factor and respond to these in an autocrine manner. Thus, the mesangial cell not only can control glomerular filtration, but may also be involved in the response to local injury, including cell proliferation and basement membrane remodeling.
Detailed explanation-2: -Contraction of mesangial cells is coupled with contraction of the basement membrane of the endothelium of glomerular capillaries. This causes a decrease in surface area of the basement membrane and thus a decreased glomerular filtration rate.
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