PHYSIOLOGY
RENAL AND ACID BASE PHYSIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Angiotensinogen is converted to angiotensin I
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Angiotensinogen is converted to angiotensin II
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Angiotensinogen raises blood pressure by vasoconstriction get the afferent arteriole
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Angiotensinogen enhances Na+ and Cl-reabsorption in the collecting ducts
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Detailed explanation-1: -Renin cleaves the N-terminal of angiotensinogen and leads to the formation of angiotensin I. This enzyme is expressed on plasma membranes of vascular endothelial cells, primarily in the pulmonary circulation. [14] It cleaves the two amino acids from the C-terminal of angiotensin I to make the peptide angiotensin II.
Detailed explanation-2: -Renin catalyzes the conversion of a plasma protein called angiotensinogen into a decapeptide (consisting of 10 amino acids) called angiotensin I. An enzyme in the serum called angiotensin-converting enzyme (ACE) then converts angiotensin I into an octapeptide (consisting of eight amino acids) called angiotensin II.
Detailed explanation-3: -The angiotensinogen (2 globulin) synthesized by hepatic parenchymal cells interacts with renin secreted by kidney juxtaglomerular cells to form a nonfunctional intermediary, angiotensin I, that in the lung becomes functional angiotensin II by the action of endothelial cells.