PHYSIOLOGY
REPRODUCTION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Sertoli’s cells
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Leydig’s cells
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Either A or B
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None of the above
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Detailed explanation-1: -Fetal Leydig cells produce the high levels of androgen (testosterone or androstenedione, depending upon the species) required for differentiation of male genitalia and brain masculinization. Androgen production declines with loss of these cells, reaching a nadir at postpartum.
Detailed explanation-2: -The Leydig cells, located in the interstitial compartment of the testis and nestled between the seminiferous tubules, produce testosterone in response to luteinizing hormone (LH), which is produced and secreted by the pituitary gland (1).
Detailed explanation-3: -Leydig cells produce testosterone in the testes under the pulsatile control of pituitary luteinizing hormone (LH). cAMP is the intracellular messenger for LH action on steroidogenesis, and pharmacological evidence indicates that the response to LH can be modulated by cyclic nucleotide phosphodiesterases (PDEs).