MEDICAL PHYSIOLOGY

Detailed explanation-1: -Free acetylcholine within the synaptic cleft is degraded by an enzyme called acetylcholinesterase. This enzyme assures that no excess of acetylcholine remains in the synaptic cleft to cause the continuous activation of receptors. Acetylcholine has different roles and functions at different synapses throughout the body.

Detailed explanation-2: -Acetylcholinesterase (AChE) is a cholinergic enzyme primarily found at postsynaptic neuromuscular junctions, especially in muscles and nerves. It immediately breaks down or hydrolyzes acetylcholine (ACh), a naturally occurring neurotransmitter, into acetic acid and choline.

Detailed explanation-3: -Acetylcholinesterase is a type-B carboxylesterase enzyme located primarily in the synaptic cleft with a smaller concentration in the extrajunctional area. Acetylcholinesterase is secreted by the muscle and remains attached to it by collagen fastened to the basal lamina.

Detailed explanation-4: -If acetylcholinesterase breaks down acetylcholine, then acetylcholinesterase function must be to eliminate the signal that acetylcholine produces. Acetylcholinesterase prevents: Overstimulation of muscle fibers. Muscle fatigue.

Detailed explanation-5: -Acetylcholinesterase (generally referred to as cholinesterase): an enzyme that rapidly breaks down the neurotransmitter, acetylcholine, so that it does not over-stimulate post-synaptic nerves, muscles, and exocrine glands.