MEDICAL PHYSIOLOGY

Detailed explanation-1: -Acetylcholinesterase (generally referred to as cholinesterase): an enzyme that rapidly breaks down the neurotransmitter, acetylcholine, so that it does not over-stimulate post-synaptic nerves, muscles, and exocrine glands.

Detailed explanation-2: -Acetylcholinesterase (AChE) is a cholinergic enzyme primarily found at postsynaptic neuromuscular junctions, especially in muscles and nerves. It immediately breaks down or hydrolyzes acetylcholine (ACh), a naturally occurring neurotransmitter, into acetic acid and choline.

Detailed explanation-3: -With the stimulation of the presynaptic terminal, acetylcholine is released from the vesicles and into the synaptic cleft, where the neurotransmitter is free to bind with receptors. Binding with receptors can have different effects depending on the area of the nervous system that acetylcholine is affecting.

Detailed explanation-4: -The acetylcholine binds to the nicotinic receptors concentrated on the motor end plate, a specialized area of the muscle fibre’s post-synaptic membrane. This binding causes the nicotinic receptor channels to open and let sodium ions enter the muscle fibre.