MEDICAL PHYSIOLOGY

Detailed explanation-1: -The binding of neurotransmitters, either directly or indirectly, causes ion channels in the postsynaptic membrane to open or close (Figure 7.1). Typically, the resulting ion fluxes change the membrane potential of the postsynaptic cell, thus mediating the transfer of information across the synapse.

Detailed explanation-2: -After release into the synaptic cleft, neurotransmitters interact with receptor proteins on the membrane of the postsynaptic cell, causing ionic channels on the membrane to either open or close. When these channels open, depolarization occurs, resulting in the initiation of another action potential.

Detailed explanation-3: -The binding of a neurotransmitter to a receptor on the postsynaptic membrane causes the associated membrane channel to change shape, allowing it to open.

Detailed explanation-4: -The molecules of neurotransmitter diffuse across the synaptic cleft and bind to receptor proteins on the postsynaptic cell. Activation of postsynaptic receptors leads to the opening or closing of ion channels in the cell membrane.

Detailed explanation-5: -(i) Opening of specific ion channels allows the entry of ions, a new action potential is generated in the post-synaptic neuron. (ii) Neurotransmitter binds to the receptor on post synaptic membrane. (iii) Synaptic vesicle fuses with pre-synaptic membrane, neurotransmitter release into synaptic cleft.