MEDICAL PHYSIOLOGY

Detailed explanation-1: -Leptin is a hormone derived from adipose tissue and the small intestine, mainly in enterocytes; it helps regulate the energy balance by suppressing hunger, resulting in decreased fat mass in adipocytes.

Detailed explanation-2: -Leptin circulates in blood and acts on the brain to regulate food intake and energy expenditure. When fat mass falls, plasma leptin levels fall, stimulating appetite and suppressing energy expenditure until fat mass is restored. When fat mass increases, leptin levels increase, suppressing appetite until weight is lost.

Detailed explanation-3: -Leptin is an appetite suppressant. When everything works the right way, it helps you maintain a healthy weight by balancing the amount of food you eat with how much fat you have. More specifically, high leptin levels tell your brain “your fat cells are full, ‘’ which makes you less hungry.

Detailed explanation-4: -Taken as a whole, leptin’s function in the body pertains to regulating the balance between food intake and energy expenditure. The classic primary physiologic role of leptin is to serve as a marker of long-term energy stores for the central nervous system (CNS).

Detailed explanation-5: -Leptin decreases your appetite, while ghrelin increases it. Ghrelin is made in your stomach and signals your brain when you’re hungry. Your fat cells produce leptin.