PHYSIOLOGY
SYNAPTIC PHYSIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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myosin
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actin
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troponin
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tropomyosin
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Detailed explanation-1: -Skeletal muscle contraction is initiated by Ca2+ ion binding to troponin C (TnC), a protein of the thin filament .
Detailed explanation-2: -Troponin plays a central role in the calcium-regulation of muscle contraction: Troponin is the sole calcium-binding component of thin filaments (actin-tropomyosin-troponin complex) of striated muscles. Thin filaments without troponin support contraction irrespective of calcium concentration.
Detailed explanation-3: -The troponin complex is made up of three components8–10: the calcium binding subunit, troponin C (TnC); the inhibitory subunit, troponin I (TnI); and an elongated protein, troponin T (TnT), that binds both TnC and TnI and anchors the entire complex to tropomyosin.