MEDICAL PHYSIOLOGY

Detailed explanation-1: -For convenience and understanding, the structure of NMJ can be divided into three main parts: a presynaptic part (nerve terminal), the postsynaptic part (motor endplate), and an area between the nerve terminal and motor endplate (synaptic cleft).

Detailed explanation-2: -The neuromuscular junction is essentially comprised of two different types of cells: skeletal muscle cells and a type of nerve cell called motor neurons. Motor neurons are covered with ion channels, which open in response to electrical signals from the brain.

Detailed explanation-3: -Across the synaptic cleft from the synaptic end bulb is a specialized region of the muscle fiber sarcolemma known as the motor end plate (postsynaptic membrane). There is one neuromuscular junction associated with each muscle fiber, and it is typically located near the middle of the fiber.

Detailed explanation-4: -Structure of Neuromuscular Junction The neuromuscular junction is composed of three major structures. The presynaptic vesicles, the synaptic cleft, sometimes called the synaptic junction, and the postsynaptic membrane of the skeletal muscle cell containing neurotransmitter receptors.

Detailed explanation-5: -The neuromuscular junction has three main parts: a presynaptic membrane, which is the membrane of an axon terminal; a postsynaptic membrane, which is the membrane of a skeletal muscle fiber and is also called a motor end-plate; and a synaptic cleft, which is the gap between the presynaptic and postsynaptic membrane.