PHYSIOLOGY
SYNAPTIC PHYSIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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They undergo phagocytosis within the PNS to remove cell debris, wastes and pathogens
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They wrap their processes around neurons and capillaries
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They are involved in producing CSF
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They are related to immune system cells such as monocytes and macrophages
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Detailed explanation-1: -A crucial function of microglia is the ability to generate significant innate and adaptive immune responses. Microglia are involved in first line innate immunity of the CNS.
Detailed explanation-2: -Microglia are the resident immune cells of the CNS. In the steady state, microglia are constantly surveilling their environment and facilitating the maintenance of synapses. These cells are characterized by a small cell body with fine, ramified processes and low expression of surface antigens.
Detailed explanation-3: -In many ways, macrophages and microglia are similar. They guard their territories and phagocytose pathogens and other offenders, and they produce an array of pro-and anti-inflammatory cytokines and growth factors, all depending on the exact stimulus that led to their activation.
Detailed explanation-4: -Microglia are resident cells of the brain that regulate brain development, maintenance of neuronal networks, and injury repair.