NEET BIOLOGY

Detailed explanation-1: -The human infection begins when an infected female anopheles mosquito bites a person and injects infected with sporozoites saliva into the blood circulation. That is the first life stage of plasmodium (stage of infection).

Detailed explanation-2: -The Plasmodium-infected mosquito injects sporozoite forms into the human host, and these migrate to the liver, where they can pass through Kuppfer cells and invade hepatocytes within which they develop into liver merozoites. These merozoites are released into the bloodstream, where they invade erythrocytes.

Detailed explanation-3: -The parasites multiply inside the red blood cells. The cells then break open within 48 to 72 hours and infect more red blood cells. The first symptoms usually occur 10 days to 4 weeks after infection, though they can appear as early as 8 days or as long as a year after infection.

Detailed explanation-4: -Merozoites infect red blood cells . The ring stage trophozoites mature into schizonts, which rupture releasing merozoites .