BIOLOGICAL CLASSIFICATION
VIRUSES
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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bonded to the viral reverse transcriptase enzyme, thus preventing the virus from making a DNA copy of its RNA genome.
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prevented host cells from producing the enzymes used by the virus to replicate its genome
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bonded to the dsDNA genome of the virus in such a way that it could not separate for replication to occur
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targeted and destroyed the viral genome before it could be reverse transcribed into DNA
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Detailed explanation-1: -After being activated by phosphorylation in vivo, AZT inhibits HIV replication by blocking a critical HIV enzyme called reverse transcriptase. This enzyme uses the virus’s RNA genome as a template to build a DNA version that can be inserted into the host’s genome.
Detailed explanation-2: -AZT is an analog of the thymidine deoxynucleoside and is a member of the class called the nucleoside-analog reverse transcriptase inhibitors.
Detailed explanation-3: -Nucleoside Reverse Transcriptase Inhibitors (NRTIs) inhibit reverse transcription by causing chain termination after they have been incorporated into viral DNA. For these drugs to be active they need to be phosphorylated intracellularly. This was the first group of antiretroviral agents to be used against HIV.