NEET BIOLOGY

Detailed explanation-1: -What does LD50 mean? LD stands for “Lethal Dose". LD50 is the amount of a material, given all at once, which causes the death of 50% (one half) of a group of test animals. The LD50 is one way to measure the short-term poisoning potential (acute toxicity) of a material.

Detailed explanation-2: -The median lethal dose (or LD50) is defined as the dose of a test substance that is lethal for 50% of the animals in a dose group. LD50 values have been used to compare relative acute hazards of industrial chemicals, especially when no other toxicology data are available for the chemicals.

Detailed explanation-3: -The new LD50 formula (LD50 = ((ED) 50/3) × Wm × 10-4) yielded value (0.29 mg/kg) of comparative significance with reported value (0.32 mg/kg). When ED50 is equal to 2LD50, the denominator of (ED) 50/3 becomes 2.

Detailed explanation-4: -Posted April 9, 2021. LD50 can be calculated using the formula LD50 = ED50/3 x Wm x 10-4. It is expressed in mg/kg bw/d or milligram of a substance per kilo of body weight administered per day.

Detailed explanation-5: -1. Botulinum toxins. Even though some of them are used in the cosmetic industry (including in botox), the botulinum family of neurotoxins includes the most toxic substances known to man. The LD50 values reported for these seven proteins are about 5 ng/kg (ng stands for nanogram, which is a billionth of a gram).