NEET BIOLOGY

Detailed explanation-1: -BPA is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). BPA absorption into the body can result in the development of metabolic disorders such as low sex-specific neurodevelopment, immune toxicity, neurotoxicity and interference of cellular pathway.

Detailed explanation-2: -BPA is classified as an Endocrine Disrupting Chemical (EDC) because it can act as a xenoestrogen. EDCs interfere and prevent the binding of natural hormones to their receptors and/or can act as a hormone mimics; consequently, they exaggerate the effects of endogenous hormones [2, 8].

Detailed explanation-3: -Due to its hormone-like properties, BPA may bind to estrogen receptors, thereby affecting both body weight and tumorigenesis. BPA may also affect metabolism and cancer progression, by interacting with GPR30, and may impair male reproductive function, by binding to androgen receptors.

Detailed explanation-4: -Results showed that BPA exposure induced lower testosterone (T) levels, while affecting the transcripts of steroidogenic gene StAR. Moreover, BPA induced abnormal germ cells proliferation in the testis in rare minnow.

Detailed explanation-5: -BPA is a known endocrine disruptor. Although initially considered to be a weak environmental estrogen, more recent studies have demonstrated that BPA may be similar in potency to estradiol in stimulating some cellular responses.