NEET BIOLOGY

Detailed explanation-1: -The use of live bacteria to induce an immune response to itself or to a carried vaccine component is an attractive vaccine strategy. Advantages of live bacterial vaccines include their mimicry of a natural infection, intrinsic adjuvant properties and their possibility to be administered orally.

Detailed explanation-2: -Disadvantages of Live, Attenuated Vaccines The major disadvantage of attenuated vaccines is that secondary mutations can lead to reversion to virulence and can thus cause disease. There is another possibility of interference by related viruses, as is suspected in the case of oral polio vaccine in developing countries.

Detailed explanation-3: -Although live, attenuated vaccines replicate, they usually do not cause disease such as that caused by the wild form of the organism. When a live, attenuated vaccine does cause disease, it is usually much milder than the natural disease and is considered an adverse reaction to the vaccine.

Detailed explanation-4: -Inactivated vaccines use the killed version of the germ that causes a disease. Inactivated vaccines usually don’t provide immunity (protection) that’s as strong as live vaccines. So you may need several doses over time (booster shots) in order to get ongoing immunity against diseases.