BIOLOGY IN HUMAN WELFARE
MICROBES IN HUMAN WELFARE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which of the following show the competitive inhibition in the pathway of cholesterol synthesis?
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Cyclosporin A
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Statins
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Streptokinase
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Citrate
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Explanation:
Detailed explanation-1: -Statins are competitive inhibitors of HMG-CoA reductase, which leads to a decrease in cholesterol synthesis in the liver.
Detailed explanation-2: -So, the correct answer is ‘Inhibition of succinic dehydrogenase by malonic acid. ‘
Detailed explanation-3: -Statins are produced by the yeast Monascus purpureus. These statins have been commercialised as blood-cholesterol lowering agents. It acts by competitively inhibiting the enzyme responsible for synthesis of cholesterol.
Detailed explanation-4: -In eukaryotes, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase is a key enzyme that catalyses the synthesis of a precusor of cholesterol as well as non-sterol isoprenoids, mevalonate.
There is 1 question to complete.