BIOTECHNOLOGY
BIOTECHNOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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It was the first vaccine developed
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It was the first antibiotic developed
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It was the first biotech drug approved by the FDA
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It was the first approved biotech treatment for AIDS
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Detailed explanation-1: -Developed by Genentech, the first American biotechnology company, Humulin was licensed to Eli Lilly and became the first marketable product created through recombinant DNA technology. Its licensing by the FDA in October 1982 also made it the first recombinant pharmaceutical approved for use in the United States.
Detailed explanation-2: -In 1982 Food and Drug Administration approved Humulin, Eli Lily’s recombinant insulin made from Genentech’s specially modified bacteria. It was the first drug produced through recombinant DNA technology and among the first genetically engineered products to be available to consumers.
Detailed explanation-3: -The first genetically engineered, synthetic “human” insulin was produced in 1978 using E. coli bacteria to produce the insulin.
Detailed explanation-4: -Humulin was the first medication produced using modern genetic engineering techniques in which actual human DNA is inserted into a host cell (E. coli). The host cells are then allowed to grow and reproduce normally, and due to the inserted human DNA, they produce a synthetic version of human insulin.
Detailed explanation-5: -In 1983, Eli Lilly an American company prepared two DNA sequences corresponding to A and B, chains of human insulin and introduced them in plasmids of E. coli to produce insulin chains. Chains A and B were produced separately, extracted and combined by creating disulfide bonds to form human insulin.