NEET BIOLOGY

Detailed explanation-1: -The uncoiling of helix structure affects the chemistry of proteins and they lose their biological activity. This phenomenon of losing their activity and uncoiling of helix structure due to physical or chemical changes is called the denaturation of proteins.

Detailed explanation-2: -Denaturation involves the breaking of many of the weak linkages, or bonds (e.g., hydrogen bonds), within a protein molecule that are responsible for the highly ordered structure of the protein in its natural (native) state. Denatured proteins have a looser, more random structure; most are insoluble.

Detailed explanation-3: -Denaturation destroys the primary structure of the protein, and the protein breaks down to monomers. Different amino acids are substituted into the sequence, so the protein’s properties change.

Detailed explanation-4: -Denaturation of proteins is an irreversible change in which proteins get precipitated when they are heated with alcohol, concentrated inorganic acids or by salts of heavy metals. Protein is uncoiled and its shape is destroyed. Characteristic biological activity is lost.