NEET BIOLOGY

Detailed explanation-1: -This change in the shape of the active site, which is usually irreversible, is called denaturation. Substrates can no longer bind to a denatured enzyme as the active site is no longer a complementary shape.

Detailed explanation-2: -denaturation, in biology, process modifying the molecular structure of a protein. Denaturation involves the breaking of many of the weak linkages, or bonds (e.g., hydrogen bonds), within a protein molecule that are responsible for the highly ordered structure of the protein in its natural (native) state.

Detailed explanation-3: -The enzymes change their shape which is known as induced fit. Enzymes can reverse back to their original shape once the reaction is carried out. Examples-ligases, salivary amylase, trypsin, maltase, etc.

Detailed explanation-4: -When an enzyme denatures, its active site changes its shape, as you can see in this diagram. This is because the protein structure of the enzyme has changed. You might notice that the active site is no longer a complementary shape to a specific substrate molecule.