NEET BIOLOGY

Detailed explanation-1: -This is called denaturing and it means that the active site is no longer a complementary shape to the substrate molecule. The substrate molecule can no longer bind to the active site and enzyme-controlled reactions can no longer occur, therefore decreasing the rate of reaction.

Detailed explanation-2: -Denaturation of enzymes causes bonds to be broken, structure to be disrupted and it stops functioning. This happens to enzymes when they are exposed to extreme, unsuitable conditions, for instance, high temperatures or extreme pH levels.

Detailed explanation-3: -When an enzyme is denatured, these bonds holding the enzyme together are disrupted, leading to a loss of structure. Depending on the degree of denaturation, only the active site of the enzyme might be affected, reducing the ability for the enzyme to effectively bind to its substrate.

Detailed explanation-4: -Temperature: Raising temperature generally speeds up a reaction, and lowering temperature slows down a reaction. However, extreme high temperatures can cause an enzyme to lose its shape (denature) and stop working.

Detailed explanation-5: -Enzyme structures unfold (denature) when heated or exposed to chemical denaturants and this disruption to the structure typically causes a loss of activity.