NEET BIOLOGY

Detailed explanation-1: -Loss of function in mitochondria, the key organelle responsible for cellular energy production, can result in the excess fatigue and other symptoms that are common complaints in almost every chronic disease.

Detailed explanation-2: -Four well-defined groups of genetic diseases in man can now be recognized in which the functions of an intracellular organelle are impaired: lysosomal storage diseases, mitochondrial disorders, endoplasmic reticulum storage diseases, and peroxisomal diseases.

Detailed explanation-3: -A few types of cells, such as red blood cells, lack mitochondria entirely. As prokaryotic organisms, bacteria and archaea do not have mitochondria.

Detailed explanation-4: -Functional stress or dysfunction of one organelle affects the other. Thus, mitochondrial stress induces a secondary lysosomal dysfunction, which produces activation of TFEB and a transcriptional response associated with lysosomal biogenesis.

Detailed explanation-5: -Widespread damage to mitochondria causes cells to die because they can no longer produce enough energy. Indeed, mitochondria themselves unleash the enzymes responsible for cell death.