NEET BIOLOGY

Detailed explanation-1: -Cell cycle checkpoints are control mechanisms that ensure the normal course of the eukaryotic cell cycle. In the cell cycle, there are three major checkpoints-the G1 checkpoint, the G2 checkpoint, and the spindle checkpoint.

Detailed explanation-2: -The main cell cycle checkpoints are the G1/S checkpoint, the intra-S checkpoint, and the G2/M checkpoint [60]. The transition through stages of the cell cycle is regulated by the action of cyclin-dependent kinases, which are key targets for modulations induced by different cellular stimuli, including DNA damage.

Detailed explanation-3: -Each step of the cell cycle is monitored by internal controls called checkpoints. There are three major checkpoints in the cell cycle: one near the end of G1, a second at the G2/M transition, and the third during metaphase.

Detailed explanation-4: -The cell cycle checkpoints play an important role in the control system by sensing defects that occur during essential processes such as DNA replication or chromosome segregation, and inducing a cell cycle arrest in response until the defects are repaired.