CELL STRUCTURES AND FUNCTION
CELL CYCLE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Anaphase checkpoint, metaphase checkpoint, and telophase checkpoint
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Interphase checkpoint, S phase checkpoint, and M phase checkpoint
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G1 checkpoint, G2 checkpoint, and S phase checkpoint
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G1 checkpoint, G2 checkpoint, and metaphase checkpoint
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Detailed explanation-1: -G1 checkpoint is near the end of G1 (close to the G1/S transition). G2 checkpoint is near the end of G2 (close to the G2/M transition). Spindle checkpoint is partway through M phase, and more specifically, at the metaphase/anaphase transition.
Detailed explanation-2: -The main cell cycle checkpoints are the G1/S checkpoint, the intra-S checkpoint, and the G2/M checkpoint [60]. The transition through stages of the cell cycle is regulated by the action of cyclin-dependent kinases, which are key targets for modulations induced by different cellular stimuli, including DNA damage.
Detailed explanation-3: -1: Internal Checkpoints During the Cell Cycle: The cell cycle is controlled at three checkpoints. The integrity of the DNA is assessed at the G1 checkpoint. Proper chromosome duplication is assessed at the G2 checkpoint. Attachment of each kinetochore to a spindle fiber is assessed at the M checkpoint.
Detailed explanation-4: -The G1 checkpoint, also known as the restriction point in mammalian cells and the start point in yeast, is the point at which the cell becomes committed to entering the cell cycle.
Detailed explanation-5: -The G2-phase checkpoint, also known as G2/M-phase checkpoint, has the function of preventing cells with damaged DNA, lasting from the G1 and S phases or generated in G2, from undergoing mitosis. The mechanisms acting during the G2-phase checkpoint converge on the inhibition of the mitotic complex CDK1-cyclin B.