NEET BIOLOGY

Detailed explanation-1: -Therefore, oriented mitotic division of epithelial cells, especially ESCs, is particularly important for wound healing.

Detailed explanation-2: -Epithelialization. All dermal wounds heal by three basic mechanisms: contraction, connective tissue matrix deposition and epithelialization. Wounds that remain open heal by contraction; the interaction between cells and matrix results in movement of tissue toward the center of the wound.

Detailed explanation-3: -It promotes the differentiation and contraction of myofibroblasts through the 2-integrin-mediated pathway and regulates the assembly of collagen fibers in the skin [58]. Additionally, lumican plays an important role in proapoptotic signaling in fibroblasts and may be important for fibrosis after wound healing.

Detailed explanation-4: -Cytokines. Cytokines have emerged as important mediators of wound healing events. By definition, a cytokine is a protein mediator, released from various cell sources, which binds to cell surface receptors to stimulate a cell response.