NEET BIOLOGY

Detailed explanation-1: -Overexpression of growth factors or a lack of suppressor proteins can lead to rapid uncontrolled cell division. As cells proliferate without regulation, tumors occur that can become deadly if not treated. Mitosis occurs infinitely.

Detailed explanation-2: -Cancers, however, occur due to an alteration of a normal biological process-cell division. Cells that progress through the cell cycle unchecked may eventually form malignant tumors, where masses of cells grow and divide uncontrollably, then develop the ability to spread and migrate throughout the body.

Detailed explanation-3: -Disruption of normal regulation of the cell cycle can lead to diseases such as cancer. When the cell cycle proceeds without control, cells can divide without order and accumulate genetic errors that can lead to a cancerous tumor .

Detailed explanation-4: -Cell cycle regulators control metabolic enzymes in cancer cells. (A) Highly proliferative cancer cells increase their glycolytic phenotype while reducing oxidative phosphorylation (OXPHOS). Since glycolytic flux is augmented the resulting pyruvate is converted to lactate and secreted extracellularly.

Detailed explanation-5: -DNA Synthesis (S phase) In many cancer cells the number of chromosomes is altered so that there are either too many or too few chromosomes in the cells. These cells are said to be aneuploid. Errors may occur during the DNA replication resulting in mutations and possibly the development of cancer.