NEET BIOLOGY

Detailed explanation-1: -c B-allele frequency (BAF) is calculated by dividing the signal intensities of minor (B) allele by those of major (A) plus minor (B) alleles. In normal sample, three values of 1, 0.5, and 0 are obtained. A gain region generates four values (e.g., 0, 0.33, 0.67, and1) and it is interpreted as allelic imbalance.

Detailed explanation-2: -Allele frequency refers to how common an allele is in a population. It is determined by counting how many times the allele appears in the population then dividing by the total number of copies of the gene.

Detailed explanation-3: -The alleles in the gene pool, 80% are A and 20% are B. After a single generation of random mating we observe Hardy–Weinberg proportions: 16 AA homozygotes, 8 AB heterozygotes, and 1 BB homozygote. Note that allele frequencies remain unchanged. Figure 2.

Detailed explanation-4: -For a three allele system: p, q and r, the frequencies can be denoted as: p2 + q2 + r2 + 2pq + 2pr + 2qr = 1. It is possible to display the data for a bi-allelic locus within a population graphically using a de Fitetti diagram. This graphical display is often referred to as the Hardy-Weinberg parabola.