NEET BIOLOGY

Detailed explanation-1: -Achondroplasia is inherited in an autosomal dominant manner. Around 80% of individuals with achondroplasia have parents with average stature and have achondroplasia as the result of a de novo pathogenic variant. Such parents have a very low risk of having another child with achondroplasia.

Detailed explanation-2: -When both parents have achondroplasia, the chance for them, together, to have a child with normal stature is 25 percent. Their chance of having a child with achondroplasia is 50 percent.

Detailed explanation-3: -This means the parents are of average height and do not have the abnormal gene. However, people with achondroplasia have a 50 percent chance to pass the gene to a child, resulting in the condition.

Detailed explanation-4: -Genetic changes happen randomly. There is nothing a parent could do before or during pregnancy to prevent this change from happening. A genetic counselor can help determine the chances of having a child with dwarfism. Depending on the type of dwarfism, two average-height parents can have a child with short stature.

Detailed explanation-5: -Only one parent needs to pass down the gene for a child to be born with achondroplasia (autosomal dominant). There is a 50% chance of a person with achondroplasia and a partner who does not have achondroplasia having a child with the disorder.