GENETICS AND EVOLUTION
GENETIC BASIS OF INHERITANCE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Tay-Sachs
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Cystic fibrosis
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Huntington’s
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PKU
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Detailed explanation-1: -Tay-Sachs disease is caused by a problem in a child’s genes that means their nerves stop working properly. A child can only have it if both parents have this faulty gene. The parents themselves don’t usually have any symptoms – this is known as being a “carrier".
Detailed explanation-2: -Tay-Sachs disease is caused by a change (mutation) in the hexosaminidase subunit alpha (HEXA) gene.
Detailed explanation-3: -The differential diagnosis for late-onset Tay Sachs disease with neurological findings includes adolescent-onset Spinal muscular atrophy, Friedreich ataxia, amyotrophic lateral sclerosis, and Kuf’s disease ( adult-onset neuronal cerebral lipofuscinosis) and late-onset forms of lysosomal storage disorders.