NEET BIOLOGY

GENETICS AND EVOLUTION

GENETIC BASIS OF INHERITANCE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Why does sickle cell disease run in families, yet is not present in every generation?
A
It is dominant, so for a person to have it, the person must inherit the gene from both parents.
B
It is recessive, so for a person to have it, the person must inherit the gene from both parents.
C
It is recessive, so for a person to have it, the person must inherit the gene from one parent.
D
It is not hereditary. Sickle Cell is is random and people randomly get it.
Explanation: 

Detailed explanation-1: -How Sickle Cell Trait is Inherited. If both parents have SCT, there is a 50% (or 1 in 2) chance that any child of theirs also will have SCT, if the child inherits the sickle cell gene from one of the parents. Such children will not have symptoms of SCD, but they can pass SCT on to their children.

Detailed explanation-2: -Inheritance. This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.

Detailed explanation-3: -Sickle Cell Anaemia is called a recessive condition because you must have two copies of the sickle haemoglobin gene to have the disorder.

Detailed explanation-4: -The sickle cell anemia trait is found on a recessive allele of the hemoglobin gene. This means that you must have two copies of the recessive allele-one from your mother and one from your father-to have the condition. People who have one dominant and one recessive copy of the allele won’t have sickle cell anemia.

Detailed explanation-5: -Scientists believe the sickle cell gene appeared and disappeared in the population several times, but became permanently established after a particularly vicious form of malaria jumped from animals to humans in Asia, the Middle East, and Africa.

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