GENETICS AND EVOLUTION
MOLECULAR BASIS OF INHERITANCE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Replace purine with pyrimidines
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Remove/Replace 3’ OH group in deoxy ribose
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Remove/Replace 2’ OH group with some other group in deoxy ribose
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Both ‘B’ and ‘C’
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Detailed explanation-1: -If 3 OH group is removed/replaced in deoxyribose, there will be no formation of pliosphodiester bonds and hence polymerisation of nucleotides will be prevented.
Detailed explanation-2: -In DNA, the nucleotides are linked together with 3-5 phosphodiester bonds. It is formed in between phosphate molecules of one nucleotide with the two sugar molecules of the other to form a polymer.
Detailed explanation-3: -Phosphodiester bonds make up the backbones of DNA and RNA. The phosphate is attached to the 5’ carbon. The 3’ carbon of one sugar is bonded to the 5’ phosphate of the adjacent sugar.
Detailed explanation-4: -DNA is a polymer of nucleotides which are linked to each other by 3’-5’ phosphodiester bonds.
Detailed explanation-5: -When nucleotides are incorporated into DNA, adjacent nucleotides are linked by a phosphodiester bond: a covalent bond is formed between the 5’ phosphate group of one nucleotide and the 3’-OH group of another (see below). In this manner, each strand of DNA has a “backbone” of phosphate-sugar-phosphate-sugar-phosphate.