GENETICS AND EVOLUTION
MOLECULAR BASIS OF INHERITANCE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Replication Forks
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Origins of Replication
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DNA Primer
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Leading Strand
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Detailed explanation-1: -The positions at which the DNA helix is first opened are called replication origins (Figure 5-29). In simple cells like those of bacteria or yeast, origins are specified by DNA sequences several hundred nucleotide pairs in length.
Detailed explanation-2: -During initiation, the replication machineries–termed replisomes–are assembled on DNA in a bidirectional fashion. These assembly loci constitute the start sites of DNA replication or replication origins.
Detailed explanation-3: -Replication begins at a specific spot called the origin of replication or ori site. Bacterial DNA has a single origin of replication. On the other hand in eukaryotic DNA there are a number of origin of replication. Replication does not take place in the absence of the ori site.
Detailed explanation-4: -The onset of genomic DNA synthesis requires precise interactions of specialized initiator proteins with DNA at sites where the replication machinery can be loaded. These sites, defined as replication origins, are found at a few unique locations in all of the prokaryotic chromosomes examined so far.