GENETICS AND EVOLUTION
MOLECULAR BASIS OF INHERITANCE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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RNA bases would start to be found in the DNA
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DNA wouldn’t unwind
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The lagging strand would elongate, but the leading strand wouldn’t
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DNA polymerase would be unable to initiate replication
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Detailed explanation-1: -Mutation of DNA primase causes extensive apoptosis of retinal neurons through the activation of DNA damage checkpoint and tumor suppressor p53. Development.
Detailed explanation-2: -In the case of a modified or mutated primase, DNA polymerase III would be incapable of producing a complementary strand; thus, RNA primers can bind to any incorrect DNA, which is why DNA replication becomes inefficient.
Detailed explanation-3: -Defective DNA Polymerase -Primase Leads to X-Linked Intellectual Disability Associated with Severe Growth Retardation, Microcephaly, and Hypogonadism.
Detailed explanation-4: -Answer and Explanation: The correct answer: The consequences to DNA synthesis if primase (the enzyme that lays down the RNA primer) were nonfunctional C. Lagging strand synthesis would be incomplete; leading strand synthesis would be unaffected.