GENETICS AND EVOLUTION
MOLECULAR BASIS OF INHERITANCE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Single-strand binding proteins bind the unwound DNA and prevent the double helix from re-forming.
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The helicase modifies the DNA in such a way as to eliminate the affinity between the two strands.
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One of the strands is rapidly degraded, preventing the double helix from re-forming.
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The helicase pushes the two strands so far apart that they have no chance of finding each other.
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Detailed explanation-1: -Single-strand binding proteins bind the unwound DNA and prevent the double helix from re-forming.
Detailed explanation-2: -Single-strand binding proteins coat the DNA around the replication fork to prevent rewinding of the DNA. Topoisomerase works at the region ahead of the replication fork to prevent supercoiling. Primase synthesizes RNA primers complementary to the DNA strand.
Detailed explanation-3: -A single-stranded DNA-binding protein is required to stabilize the unwound template, and the DNA polymerase -primase complex then initiates DNA synthesis.
Detailed explanation-4: -To ensure that unwound regions of the parental DNA remain single-stranded and available for copying, the separated strands of the parental DNA are bound by many molecules of a protein called single-strand DNA binding protein (SSB).
Detailed explanation-5: -Single strand binding protein (ssb protein) binds to separated strands of DNA and prevents reannealing. Primase complexes with helicase, creates RNA primers (pppAC(N)7-10) on the strands of the open duplex2 (Primase+helicase constitute the Primosome).