NEET BIOLOGY

GENETICS AND EVOLUTION

MOLECULAR BASIS OF INHERITANCE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
The function of DNA polymerase I is to ____
A
add nucleotide complements to the growing strand.
B
remove the RNA primer.
C
bond the Okazaki fragments together on the lagging strand.
D
keep the DNA strands from reforming after DNA helicase “unzips” them.
Explanation: 

Detailed explanation-1: -DNA polymerase I of eubacteria functions in vivo to synthesize short stretches of DNA during excision repair and to remove RNA primers and fill the gaps between Okazaki fragments in lagging strand replication.

Detailed explanation-2: -DNA polymerase I and II have a role to play in repair, removing the primer and filling the gaps. In eukaryotes, DNA polymerase is the main enzyme for replication. Other DNA polymerases are involved in the repair, proofreading and primer removal.

Detailed explanation-3: -The RNA primers are removed and replaced by DNA through the activity of DNA polymerase I, the other polymerase involved in replication. The nicks that remain after the primers are replaced get sealed by the enzyme DNA ligase.

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