GENETICS AND EVOLUTION
MOLECULAR BASIS OF INHERITANCE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which set of enzymes is involved in nucleotide excision repair?
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nuclease, DNA polymerase, and ligase
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DNA polymerase, helicase, primase
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ligase, nuclease, and primase
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nuclease, DNA polymerase, primase
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Explanation:
Detailed explanation-1: -The process of nucleotide excision repair is controlled in Escherichia coli by the UvrABC endonuclease enzyme complex, which consists of four Uvr proteins: UvrA, UvrB, UvrC, and DNA helicase II (sometimes also known as UvrD in this complex).
Detailed explanation-2: -DNA Ligases I and III Support Nucleotide Excision Repair in DT40 Cells with Similar Efficiency.
Detailed explanation-3: -The resulting single-stranded gap undergoes repair DNA resynthesis and ligation by DNA polymerase III holoenzyme, SSB, and DNA ligase. The excision-repair tracts associated with this pathway can be a kilobase long or longer. Hence, this repair system is referred to as the ‘long-patch repair system.
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