NEET BIOLOGY

Detailed explanation-1: -Mast cells and basophils represent the most relevant source of histamine in the immune system. Histamine is stored in cytoplasmic granules along with other amines (e.g., serotonin), proteases, proteoglycans, cytokines/chemokines, and angiogenic factors and rapidly released upon triggering with a variety of stimuli.

Detailed explanation-2: -Histamine is secreted by basophils. Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. Histamine is involved in the inflammatory response.

Detailed explanation-3: -Mast cells are multifunctional bone marrow-derived tissue-dwelling cells that are the major producer of histamine in the body.

Detailed explanation-4: -Complete answer: Histamine, serotonin, and heparin are secreted by the mast cells during inflammation and allergic reactions. A type of granular basophil cell consists of mast cells.

Detailed explanation-5: -In addition to fighting parasitic infections, basophils play a role in: Preventing blood clotting: Basophils contain heparin. This is a naturally occurring blood-thinning substance. Mediating allergic reactions: In allergic reactions, the immune system is exposed to an allergen.