NEET BIOLOGY

Detailed explanation-1: -Overview of megakaryopoiesis and thrombopoiesis Megakaryopoiesis is the process by which a hematopoietic progenitor cell (HPC) differentiates into a large polyploid megakaryocyte, whereas thrombopoiesis is the process by which platelets are released from megakaryocytes.

Detailed explanation-2: -Platelets, or thrombocytes, are small, colorless cell fragments in our blood that form clots and stop or prevent bleeding. Platelets are made in our bone marrow, the sponge-like tissue inside our bones.

Detailed explanation-3: -Each megakaryocyte has been estimated to generate and release thousands of platelets (50–52). If platelet formation is restricted to a relatively limited number of proplatelet ends, platelets would have to form and release on a minute time scale.

Detailed explanation-4: -The primary function of megakaryocytes is to synthesize and assemble platelet components and organelles. Although debated for a long time, new data seems to indicate that the lung may be a central locus of platelet production.