NEET BIOLOGY

Detailed explanation-1: -The process of erythropoiesis takes place in bone marrow where the RBC maturation takes place. The process of erythropoiesis is carried out by the factor vitamin B12 and folic acid. This work in conjunction to produce mature RBC.

Detailed explanation-2: -Erythroblasts require folate and vitamin B12 for proliferation during their differentiation. Deficiency of folate or vitamin B12 inhibits purine and thymidylate syntheses, impairs DNA synthesis, and causes erythroblast apoptosis, resulting in anemia from ineffective erythropoiesis.

Detailed explanation-3: -Vitamin B-12 works in conjunction with another B vitamin, folate, to produce red blood cells. Without proper amounts of vitamin B-12, DNA production is impaired, resulting in abnormal red blood cells. Hence, option A is correct.

Detailed explanation-4: -Your body needs vitamin B12 to make red blood cells. In order to provide vitamin B12 to your cells: You must eat foods that contain vitamin B12, such as meat, poultry, shellfish, eggs, fortified breakfast cereals, and dairy products.

Detailed explanation-5: -Several vitamins play important roles in hematopoietic system. Vitamin B12, C and folic acid are associated with DNA synthesis of erythroid nucleus, the deficiency of which causes the megaloblastic anemia. Some megaloblatic anemia and sideroblastic anemia might response to vitamin B1 and B6, respectively.