HUMAN PHYSIOLOGY
DIGESTION AND ABSORPTION
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
|
|
Matured chylomicrons are synthesized in intestinal epithelial cells
|
|
|
On the capillary wall near the tissues, there is the enzyme lipoprotein lipase which will be activated by ApoE (in chylomicron)
|
|
|
Once lipoprotein lipase is activated, it will degrade TG to form FA + glycerol
|
|
|
Chylomicron remnant goes to the liver by receptor mediated endocytosis
|
|
|
Receptor on liver recognizes ApoC-II from chylomicron remnants
|
Detailed explanation-1: -The uptake of chylomicron remnants by the liver has been hypothesized to involve sequestration in the space of Disse, processing at the cell surface, and internalization by parenchymal cells via receptor-mediated endocytosis.
Detailed explanation-2: -Chylomicron remnants deliver dietary cholesterol to the liver. It is then incorporated into very low-density lipoproteins (VLDL), which are secreted in plasma.
Detailed explanation-3: -Chylomicrons (Fig. 20-14) are formed in the intestinal epithelium to transport long-chain triglycerides to the tissues. Medium-and short-chain fats are transported directly to the liver through the portal circulation without packaging into lipoprotein particles.
Detailed explanation-4: -On the endothelium surface of capillaries, chylomicron triglycerides are broken-down by lipoprotein lipase (LPL); the lipolysis products, fatty acids and glycerol are stored in adipose and muscle tissues and the resulting triglyceride-depleted remnants are finally taken-up by the liver [1, 2].