NEET BIOLOGY

Detailed explanation-1: -An enzyme made in the stomach that breaks down proteins in food during digestion. Stomach acid changes a protein called pepsinogen into pepsin.

Detailed explanation-2: -Pepsins are a family of proteolytic enzymes that initiate protein digestion in the stomach.

Detailed explanation-3: -Pepsin Pearls Pepsin is a stomach enzyme that serves to digest proteins found in ingested food. Gastric chief cells secrete pepsin as an inactive zymogen called pepsinogen. Parietal cells within the stomach lining secrete hydrochloric acid that lowers the pH of the stomach. A low pH (1.5 to 2) activates pepsin.

Detailed explanation-4: -Pepsin is an endopeptidase that preferentially hydrolyzes peptide linkages where one of the amino acids is aromatic and accounts for approximately 20% of the protein digestion in the GI tract.

Detailed explanation-5: -Pepsin is expressed as a zymogen called pepsinogen, whose primary structure has an additional 44 amino acids compared to the active enzyme. In the stomach, gastric chief cells release pepsinogen.