NEET PG DENTAL EXAM

Detailed explanation-1: -Microglia are currently considered to be the major phagocytes in the brain parenchyma, and these cells phagocytose a variety of materials, including dead cell debris, abnormally aggregated proteins, and, interestingly, the functional synapses of living neurons.

Detailed explanation-2: -Microglia are a type of neuroglia (glial cell) located throughout the brain and spinal cord. Microglia account for about 10-15% of cells found within the brain. As the resident macrophage cells, they act as the first and main form of active immune defense in the central nervous system (CNS).

Detailed explanation-3: -Microglia, the innate immune cells of the brain, are indispensable for proper brain development. As professional phagocytes, microglia engulf other cells within distinct developmental niches to sculpt the architecture of the brain.

Detailed explanation-4: -Microglia are the brain’s main phagocytes (cells capable of engulfing and digesting large extracellular particles), and protect the brain by phagocytosing bacteria, aggregated proteins and cellular debris (Galloway et al., 2019; Vilalta & Brown, 2018; Wolf et al., 2017).