BRAIN
SPINAL CORD
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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If voltage-gated sodium channels were blocked, what effect would it have on the function of neurons?
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the dendrites could not receive signals
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the dendrites could not have temporal summation
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the axon would repeatedly generate an action potential
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the axon could not generate an action potential
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Explanation:
Detailed explanation-1: -In the open state, voltage-gated sodium channels form a pore in the cytoplasmic membrane that allows sodium ions to flow into the cell, depolarizing the cell and generating the upstroke of the action potential; however, most sodium channels rapidly transit into the “inactivated” state at depolarized potentials.
Detailed explanation-2: -Block of voltage-gated potassium (Kv) channels has been demonstrated to affect neuronal activity described as increasing excitability. The effect has been associated with a closed-state dependent block. However, the block of Kv channels in e.g. local anesthetic and antiarrhythmics, is open state-dependent.
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