BRAIN
SPINAL CORD
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which morphogen is responsible to determining ventralisation of the neural tube?
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BMP
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WNT
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HOX
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SHH
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RA
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Explanation:
Detailed explanation-1: -Secreted signals, known as morphogens, provide the positional information that organizes gene expression and cellular differentiation in many developing tissues. In the vertebrate neural tube, Sonic Hedgehog (Shh) acts as a morphogen to control the pattern of neuronal subtype specification.
Detailed explanation-2: -In ventral regions of the presumptive spinal cord, the secreted molecule sonic hedgehog (Shh) acts as a long-range morphogen(Box 1) that directs the pattern of neurogenesis by conferring positional information to ventral neural progenitors (see Jessell, 2000; Lupo et al., 2006). Here, the Shh signaling pathway(Fig.
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