NEET PG DENTAL EXAM

EMBRYOLOGY

CHROMOSOMES AND CELL DIVISIONS

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Why are insertion and deletion (frameshift) mutations so harmful?
A
They change all of the codons from the mutation on down the line, which changes the amino acid sequence
B
They insert things that an organism doesn’t need.
C
They often delete things that organisms need.
D
Insertion and deletions are not any more harmful than substitution mutations.
Explanation: 

Detailed explanation-1: -Frameshift Mutation If a mutation disrupts this normal reading frame, then the entire gene sequence following the mutation will be incorrectly read. This can result in the addition of the wrong amino acids to the protein and/or the creation of a codon that stops the protein from growing longer.

Detailed explanation-2: -Insertion or deletion of one or more nucleotides during replication can also lead to another type of mutation known as a frameshift mutation. The outcome of a frameshift mutation is complete alteration of the amino acid sequence of a protein.

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