NEET PG DENTAL EXAM

Detailed explanation-1: -Mechanosensitive channels, mechanosensitive ion channels or stretch-gated ion channels are membrane proteins capable of responding to mechanical stress over a wide dynamic range of external mechanical stimuli. They are present in the membranes of organisms from the three domains of life: bacteria, archaea, and eukarya.

Detailed explanation-2: -Channels that respond to stretch, curvature, or deformation of the membrane are classified as mechanosensitive, even though the details of how a particular stimulus leads to altered channel function is rarely known. Osmotic or hydrostatic swelling or shrinkage of cells also regulate certain channels.

Detailed explanation-3: -Mechanically-gated ion channels are responsible for sensing touch, pressure and acoustic in biology (Delmas and Coste, 2013; Ranade et al., 2015). To understand how membrane proteins gate ionic channels, supported lipid membranes have been constructed on electrochemical electrodes.

Detailed explanation-4: -Stretch-activated Ion Channels SACs are believed to respond to mechanical forces along the plane of the cell membrane (membrane tension), but not to hydrostatic pressure perpendicular to it.