EMBRYOLOGY
PLACENTA FETAL MEMBRANES BIRTH DEFECTS AND TWINING
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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growth hormone GH
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GNRH
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Insulin-like growth factor (IGF 1)
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None of the above
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Detailed explanation-1: -Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in response to the endocrine GH stimulus, but it is also secreted by multiple tissues for autocrine/paracrine purposes.
Detailed explanation-2: -Growth delay due to insulin-like growth factor I deficiency is characterised by the association of intrauterine and postnatal growth retardation with sensorineural deafness and intellectual deficit.
Detailed explanation-3: -IGF-I is an important stimulant of protein synthesis in muscle but it also stimulates free fatty acid utilization. Important indirect effects of IGF-I that influence metabolism include suppression of growth hormone secretion and at supraphysiologic concentrations suppression of insulin secretion.